@larryboylarry5557
I learn so much from you guys but forget most of it. Like all the references you made to your thyroid series. I'm like "I don't remember that part." Many times. I am hypothyroid and working on getting euthuroid. It really does affect the memory badly. I have made diet changes and it has helped me overall. But I cannot find anybody in the medical field who will look at my problem the way you guys do or many functional medicine doctors. Insurance doesn't cover 'alt medicine' so I have a tough row to hoe. I really appreciate you guys! Thank you so much for spending your time educating us.
@MassiveOverkill
54 year old male, ketovore who eats a ton of oxalates daily: Turmeric Cocoau powder Peanuts and peanut butter Walnuts Mixed nuts Celery Lemon peel (from whole lemon) Black pepper Carrot and I truly believe I can handle all the above daily because my guy health has never been better. I also eat garlic and onions at least weekly. I avoid all seed oils. I do have high vitamin D levels from supplement and sunbathing along with magnesium (380 mg) and other micros. I eat homemade l. reuteri yogurt daily as well. I also take tudca. I do sort of frown on lumping carnivore/keto into the same category.
@cammieklund
Around 7 min in. I can attest to the fact that ALL of these symptoms can be oxalate related. The body can tuck away oxalates in every tissue, that's why there are so many different symptoms. BUT! All of the symptoms mentioned can also ofc be bcs of other things aswell.
@doloresguertin9601
Thanks Jay, thanks Mike, you shared a lot of good info. In terms of excretion of oxalates, yiu focused on urinary excretion, but I missed any discussion sbout excretion from eyes, skin, lungs, salivary glands, and colon. People may consider these exit routes less common but they are increasingly more common, just not studied as extensively. In fact urinary excretion was not the preferred route for my body to take, but it's not over, so I shouldn't speak too soon, approaching 7 yrs and still dumping. I would love to meet with you Jay. <3D
@kolanikola-m9x
Thanks guys for very useful information!
@cammieklund
I haven't seen this yet, but I can tell from my personal experience that oxalate toxicity is 100% real. It literally led to me becoming bedridden and having to live on disability. I'm still clearing oxalate crystals out of my skin, scalp, urine and eyes after 3 years on low oxalate eating. The information from Sally K Norton saved my life. Nobody, atleast not Sally, says to 100 % eliminate oxalate containing foods though! It's even important to keep some in the diet when you have eaten a lot so you don't start to dump out too quickly. I sadly went too low to quickly and that landed me in the ER on multiple occasions. I have still abnormal EKG (actually sitting with a 7 day EKG monitor right now to track my arythmias) and I don't know if this has created permanent damage to my heart. Anyways...It's going to be interesting to hear what you are going to say. I've spoken to Sally regarding coming on as a guest on your show and she is up to it. I wrote about this in email to you and your assistant declined. Sally has done research on oxalates for about 11 years so she really knows what she is talking about. Lots of faulty data out there sadly. Hopefully you'll change your mind bcs this is a super important topic. And it's way more nuanced than most people think. Sally talks about all these nuances, like endogenous production and so on, but people that don't really follow her don't know everything she says. I've been to probably around 70 of her classes and it's VERY nuanced.
@jx2938
Yay! Anytime I listen to someone making claims that a certain food is poison I always want to hear what Jay and Mike would say 🤣
@dennisward43
This talk of oxalates reminds me of ldl-cholesterol which is mostly endogenously created and often blamed for things like atherosclerosis that can be caused in multiple ways. The big difference is that cholesterol is an essential chemical that is vital in every cell of the body whereas oxalates are definitely non-essential. Another difference is that there is much less money to be made by big pharma companies from reducing oxalates.
@jirihutecka9020
For me oxalates are real issue. The worst part is that I love all high oxalate foods. For example potatoes. But if I have like 500g for couple of days my hip joints start to hurt like it needs replacement, my spine gets insanely stiff and when I use ear plugs for sleeping I can hear sand like sound in my neck spine when I turn my head.. I was also eating buckwheat a lot for a long time. Couldn't figure out why my eyes are so red and irritated all the time like I have some sand in them. So for me it is a must to keep eye on oxalate intake and I simply can't eat foods that are high or even moderate in oxalate content..
@revolutionancestrale
Hello Jay and Mike, Thank you for addressing this topic. I find it essential that it is discussed outside of ketogenic or carnivore circles. You bring up some great points, and I also believe that endogenous oxalate synthesis is an underestimated factor in this issue, especially in highly specific diets. That being said, I think the general picture you present regarding absorption—specifically that it would be "insignificant" in a healthy individual via diet—seems inaccurate for several reasons. First, a diet containing 250 mg of oxalates per day is not a high-oxalate diet. This is a moderate intake that should not cause immediate problems in a healthy individual or saturate our excretion capacity. I encourage you to calculate how easy it is to exceed 250 mg daily simply by consuming potatoes, cocoa, beets, almonds, spinach, buckwheat, etc. Without awareness of the issue, it’s quite common to surpass this threshold. Now, the main problem. The studies cited estimate absorption based on urinary excretion, not on oxalates actually circulating in the blood, which is much harder to measure. While this method is relatively accurate for low-to-moderate oxalate diets, it becomes much less reliable as dietary intake increases, simply because renal excretion capacity is limited. This explains why high-oxalate diets appear to have a lower percentage of absorption when, in reality, what’s being measured is the percentage of excretion. This is evident in the Hess et al. study, which reports an excretion of "only" 70 mg/day—already well above normal renal capacity—indicating that the body is activating emergency mechanisms to expel oxalates, potentially by increasing blood pressure or other means. We can be certain that some oxalates are being deposited in kidney tissues as part of this emergency response. These numbers do not accurately measure absorption; they measure excretion. They only hold relevance if one assumes that oxalate deposition in tissues is either a myth or insignificant, which contradicts existing research on the subject. These studies completely overlook the deposition of oxalates in tissues—a process that increases with concentration. Vermeulen’s studies have shown that oxalates accumulate in various tissues even when normal renal excretion capacity is not exceeded but merely approached. Moreover, tissues and organs accumulate oxalates at higher concentrations than those found in the blood, suggesting that the body is making every effort to lower circulating oxalate levels. This should not surprise us, as circulating oxalates can cause far more damage than when they are immobilized in tissues. A study in humans found oxalate deposits in the thyroids of over 73% of individuals and even 85% of those over 70 years old. Other studies have also identified oxalate deposits in various tissues. Unfortunately, such studies remain rare, as they require biopsies. Additionally, I couldn’t find details on the specific diets used in the study you referenced. Variations in soluble vs. insoluble oxalates or other factors could significantly impact both excretion and absorption rates. Another crucial point: these short-term studies do not account for the fact that chronic high oxalate intake gradually damages gut integrity and microbiota, which in turn increases absorption over time. I don’t think it's necessary to promote excessive fear of oxalates or to aim for lifelong intakes below 50 mg, but the message I took from your discussion was that dietary oxalates are not really a concern for healthy individuals because absorption supposedly decreases with higher intake. I don’t think that’s the right takeaway. That being said, I completely agree with you that many factors must be considered in this discussion—whether to limit absorption, reduce endogenous synthesis, or enhance excretion. One last point: Mike seemed to suggest that citrate intake reduces absorption. That is not the case. Citrates can actually increase absorption by precipitating insoluble oxalates, thereby freeing oxalic acid. However, citrates are very useful for dealing with endogenous or already absorbed/stored oxalates, helping to facilitate gentle excretion. Consuming citrates alongside a high-oxalate meal does not seem like a good strategy to me. Thx for reading.
@skincraftorganicsllc8537
Excellent!! I'm so sick of every health issue being attributed to a specific thing like oxalates, lectins, seed oils, etc.!! Yes, they MAY cause issues, BUT when on an Oxalate Facebook group, EVERY single issue, from a pimple to much more is due to oxalates... nevermind that many of these people, while omitting high oxalate foods, continue to eat a crappy diet - highly refined and processed... ughhhh!!! Also, is "dumping " even a REAL THING??
@joecaner
"A dietary survey undertaken in the Western Highlands in 1972 showed that the diet consisted almost entirely of sweet potato. The daily energy intake was 2300 for males and 1770 kilocalories for females. [T]otal energy intake [was] 94%...carbohydrate, 3% from protein and 2.4% from fat (76). Adults were consuming only 25g of protein per day. [I]n spite of their low protein intake, the New Guineans represented a remarkably healthy group." It would seem that these New Guinean highlanders were not getting anything like 1000mg of calcium and eating a lot of sweet potatoes without developing kidney stones.
@RamintaGar
If my understanding is correct, long term sick or under-eating people lose up to half of lean body mass. To regrow the internal organ and structure the body releases stress hormones. The regrow follows the body field, like a salamander's tail. The stress hormones make people gain body fat. All body cells change in 7 years, but some organs can change in a few weeks like the liver. If an adult has the organs of the size of the child, will the regrowth follow the pattern of growing child into the adult or will it be faster because the body field belongs to an adult (like a salamander's tail). How long will it take to regrow the lean body mass and to stop the stress hormones cascade? Georgi Dinkov was talking about high stress hormone levels in sick people. Youtube channel Stronsistas talks about organ size. Jay Feldman Wellness talks about carb metabolism. And they all are followers of Ray Peat.
@vanessac1965
Oxalates are very important re younger women who get breast cancer. The oxalates accumulate in the breast tissue and create calcifications that turn into tumours. I'd love you guys to address candida as a cause of endogenous oxalate production
@sabrinakisch3681
Very interesting about the soluble versus insoluble oxalates. I've searched online for a list breaking out soluble vs insoluble oxalates in foods, and found nothing. Where can one find such a list?
@marynguyen6417
Even if the oxalate absorption does not increase proportionally with the amount of oxalate being consumed as mentioned in this podcast, it still doubles or triples the amount compared to a low oxalate diet. Would the fact that because the oxalate is so damaging to the body that doubling or tripling the amounts as mentioned would be more than enough to cause havoc on our health. So to me, keeping a minimum oxalate consumption is still extremely important.
@friedux2065
Antibiotics and c19 wiped out all my oxolobacter and bifido according to biomesight :(, I have had bad issues with oxalate since then.
@jeremy8365
Is carbohydrate spill over a thing? If I were to eat a surplus of glucose every day and my muscle glycogen stores get completely full, is this a good thing? Is this ideal? What happens to excess glucose after that? Or is it better to match your daily glucose requirements without excess dietary glucose? I lift weights and want to lower my fat to the minimum and max out my carbs with more starchy potato, is keeping your glycogen stores full actually a good thing? I assume I would only gain body fat if there is a surplus of calories, but if I kept my calories at around maintenance or slight surplus to promote muscle growth but had a surplus of dietary glucose and my glycogen stores are full, what happens? Thank you!
@StephanieKraft
Why would it matter how much oxalates we're absorbing, when there's horrible damage being done as it's excreted as well as from what's absorbed? Both are damaging.
@adityasangore5323